It constitutes approximately 3% of the malignant neoplasms of the pleura and, when its diagnosis is confirmed, its course is usually fatal in the long term. One of the most important characteristics in the diagnosis of a patient affected by mesothelioma is the stage in which the cancer is found.
Stage 4 Pericardial Mesothelioma cancer is the final stage and the most serious of all. It is quite advanced. The tumors have already invaded multiple parts of the chest wall, the pericardium, diaphragm or distant organs to the lymph nodes. Stage IV mesothelioma may not be detected by a CT Scan or PET Scan. Magnetic resonance imaging is the most recommended technique for detecting cancer metastasis. Mesothelioma symptoms near death are quite severe. Palliative treatments are usually necessary.
Phase 4 Pleural Mesothelioma Information
In stage IV asbestos cancer, the tumors have spread from the point of origin in the lungs, heart or abdomen. The most common symptoms for stage IV mesothelioma is shortness of breath, abdominal tightness, and pain. Other common symptoms include the following:
Doctors use diagnostic testing, such as MRIs and PET scans, to locate the disease. The best prognostic tests include biopsies and surgery to determine the stage.
Phase 4 Mesothelioma Therapy
During the last stage of cancer, some people aren’t able to get surgery on account of how the cancer is infected in areas that may not be managed on. But one optional way at this point if corrective operation.
Frequent palliative therapies include:
Chemotherapy, immunotherapy and other personalized therapies
Chemotherapy, immunotherapy, and radiotherapy can achieve better control of the disease. From passive immunotherapy to the modulation of the immune response by dendritic or other cells, there is a wide spectrum of possibilities to achieve markedly synergistic anti-tumor effects.
The control of pleural effusion is a priority in most patients with malignant pleural mesothelioma, and talc pleurodesis may be a good option. However, in our experience, more failures of pleurodesis occur in this tumor than in others, and this could be attributed to the inability to adequately re-expand the lung, enclosed by the tumor.
Is Curative Surgery a better Option at Stage 4 Mesothelioma?
The Stage 4 Mesothelioma Treatment Options depend on whether cancer can be removed by surgery. Your healthcare team will offer you treatments according to your needs and will discuss with you to develop a treatment plan.
Surgery is not usually offered to people with stage 4 pleural mesothelioma because it is an aggressive tumor that recurs (recurrence) quickly after treatment. Depending on the stage of pleural mesothelioma, the following treatment option may be used.
Mesothelioma responds to radiotherapy, but given its extension at the time of diagnosis, the treatment fields are broad, which makes its application difficult without significant risks for the adjacent structures. Three possible utilities have been pointed out in the management of mesothelioma:
• As prophylaxis of “tumor seeding” after carrying out biopsies or placement of drainages.
• As a palliative treatment of pain.
• As an adjunct to extrapleural pneumonectomy as part of a multimodal treatment plan
Patients should have to think about to participate in a clinical trial.
For some patients, participation in a clinical trial may be the best treatment option. Clinical trials are being conducted to determine whether new cancer treatments are safe and effective, or even superior to standard treatment.
Patients who participate in a clinical trial may receive the standard treatment or be among the first to receive a new treatment. Patients who participate in clinical trials also help to improve how cancer will be treated in the future. Even when clinical trials do not lead to effective new treatments, they often answer important questions and help advance research.
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