//

What effect does an anaesthetic have on my child’s brain development?

There have been many concerns in recent times regarding the safety of children having general anaesthetics and what implications it may have on brain development.  These concerns of anaesthesia-related neurological injury have not only been voiced by parents, but also increasingly amongst health-care providers and regulatory organisations. Animal studies suggest prolonged general anaesthetics cause brain […]

There have been many concerns in recent times regarding the safety of children having general anaesthetics and what implications it may have on brain development.  These concerns of anaesthesia-related neurological injury have not only been voiced by parents, but also increasingly amongst health-care providers and regulatory organisations.

Animal studies suggest prolonged general anaesthetics cause brain injury in animals

In 2003, a study published in the Journal of Neuroscience observed the effects on the developing brain on 7 day old infant rats exposed to commonly used Anaesthetic medications (midazolam, nitrous oxide and isoflurane) in doses sufficient to maintain an anaesthetic for 6 hours. The results showed widespread apoptotic neurodegeneration (brain cell death) in the developing brain and persistent learning and memory impairment.

US Food and Drug Administration (FDA) release warning concerning Anaesthetic agents in children

On the 27th April 2017, the US Food and Drug Administration (FDA) released a drug safety communication regarding using General Anaesthetic and sedation drug in pregnant women and young children. The statement was as follows:

  • A new Warning stating that exposure to these medicines for lengthy periods of time or over multiple surgeries or procedures may negatively affect brain development in children younger than 3 years.
  • Addition of information to the sections of the labels about pregnancy and peadiatric use to describe studies in young animals and pregnant animals that showed exposure to general anaesthetic and sedation drugs for more than 3 hours can cause widespread loss of nerve cells in the developing brain; and studies in young animals suggested these changes resulted in long-term negative effects on the animals’ behaviour or learning.

Without direct human studies, the evidence up to this point was on animals and made clinical interpretation very difficult.

New study provides vital information regarding safety of Anaesthetic Agents in Children

A study that has just been published in the Lancet journal (Neurodevelopmental outcome at 5 years of age after general anaesthesia or awake-regional anaesthesia in infancy (GAS): an international, multi-centre, randomised, controlled equivalence trial) has given the medical community the best evidence so far. The study aimed to investigate whether exposure to general anaesthesia in young children adversely affects longer-term neurodevelopmental outcomes as compared with awake-regional anaesthesia. 

The studied recruited more than 700 infants who underwent hernia operations at two years of age and then at five years old. These children were allocated to either a general anaesthetic or a regional anaesthetic. This study involved 28 hospitals in Australia, New Zealand, the US, Canada and Europe. These patients were observed between February 2007 and January 2013. The trial tested the neurobehavioural and cognitive development of more than 700 infants who underwent hernia surgery (one of the most common operations of early childhood) at two years of age and then at five years. The children were allocated either a general anaesthetic or a regional (local) anaesthetic.

The results showed that one brief general anaesthetic in early childhood is unlikely to be harmful to long-term neurodevelopment but the safety of longer exposures remains unclear.  The results also showed no significant difference in IQ scores between the children exposed to general anaesthesia (average IQ score 98.87) and regional anaesthesia (99.08), after adjusting for age at birth and country, and accounting missing data. There were also no differences in a range of other tests of neurobehavioural and cognitive function.

This study is very important as nearly half of all general anaesthetics that are performed in children under the age of five are short in duration. The Anaesthetists from Anaesthetic billing company, Fast Tracking Anaesthetic Billing Services believes that this will provide the necessary reassurance to parents and health providers that general anaesthetics.

Conclusion

Given the new information provided by the GAS study, we can now be confident that a single general anaesthetic under the age of five for a duration less than one hour has no effect on neurobehavioural and cognitive function.

    Share your comments below. Please read our commenting guidelines before posting. If you have a concern about a comment, report it here.

    You might also like...

    Science//

    New Study May Reveal Secrets Of The Teenage Brain

    by Shelby Lorman
    Community//

    One Thing You Can Do Every Day to Protect Your Child’s Brain Health

    by Tonya Harris, MSHN, BCHN
    Brain Injuries among Children
    Community//

    Traumatic Brain Injury Among Children

    by Sean M. Cleary

    Sign up for the Thrive Global newsletter

    Will be used in accordance with our privacy policy.

    Thrive Global
    People look for retreats for themselves, in the country, by the coast, or in the hills . . . There is nowhere that a person can find a more peaceful and trouble-free retreat than in his own mind. . . . So constantly give yourself this retreat, and renew yourself.

    - MARCUS AURELIUS

    We use cookies on our site to give you the best experience possible. By continuing to browse the site, you agree to this use. For more information on how we use cookies, see our Privacy Policy.